From Paulsen Laboratory
Strains of Burkholderia cenocepacia are commonly isolated from the soil/rhizosphere and from the lungs of Cystic fibrosis (and other immunocompromised) patients. these bacteria are multidrug resistant and are difficult to treat in the clinical setting. they can in a way be considered model organisms since they possess multi-replicon genomes and have broad metabolic capacity. This project involves utilizing high throughput technologies such as Genome sequencing, RNA-seq, quantitative proteomics and global metabolic profiling to study Australian clinical strains of B.cenocepacia, with the objective of obtaining a systems level understanding of this versatile organism.