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Phylogenetics of Transporter Families

Protein sequence in FASTA format
Multiple sequence alignment (View it with JalView)
Multiple sequence alignment (Alignment text file for if JalView does not work, we recommend you run JalView locally in this situation)
Newick Format Tree Text Document (Download and view it with FigTree)
Phylogenetic tree (Phylogram) (View it with Archeopteryx)
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ABC: The ATP-binding Cassette (ABC) Superfamily

ArsAB: The Arsenite-Antimonite (ArsAB) Efflux Family

F-ATPase: The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily

H+-PPase: The H+-translocating Pyrophosphatase (H+-PPase) Family

IISP: The Type II (General) Secretory Pathway (IISP) Family

MPT: The Mitochondrial Protein Translocase (MPT) Family

P-ATPase: The P-type ATPase (P-ATPase) Superfamily

Ion Channels

ACC: The ATP-gated Cation Channel (ACC) Family

Amt: The Ammonia Transporter Channel (Amt) Family

Annexin: The Annexin (Annexin) Family

Bcl-2: The Bcl-2 (Bcl-2) Family

CD20: The CD20 Ca2+ Channel (CD20) Family

Connexin: The Gap Junction-forming Connexin (Connexin) Family

E-ClC: The Epithelial Chloride Channel (E-ClC) Family

ENaC: The Epithelial Na+ Channel (ENaC) Family

GIC: The Glutamate-gated Ion Channel (GIC) Family of Neurotransmitter Receptors

Hsp70: The Cation Channel-forming Heat Shock Protein-70 (Hsp70) Family

ICC: The Intracellular Chloride Channel (ICC) Family

Innexin: The Gap Junction-forming Innexin (Innexin) Family

IRK-C: The Inward Rectifier K+ Channel (IRK-C) Family

LIC: The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family

MID1: The Yeast Stretch-Activated, Cation-Selective, Ca2+ Channel, Mid1 (Mid1) Family

MIP: The Major Intrinsic Protein (MIP) Family

MIT: The CorA Metal Ion Transporter (MIT) Family

MscL: The Large Conductance Mechanosensitive Ion Channel (MscL) Family

MscS: The Small Conductance Mechanosensitive Ion Channel (MscS) Family

NSCC2: The Non-selective Cation Channel-2 (NSCC2) Family

PCC: The Polycystin Cation Channel (PCC) Family

PLM: The Phospholemman (PLM) Family

RIR-CaC: The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family

TRP-CC: The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family

UAC: The Urea/Amide Channel (UAC) Family

UT: The Urea Transporter (UT) Family

VIC: The Voltage-gated Ion Channel (VIC) Superfamily

Outer Membrane Porins

MPP: The Mitochondrial and Plastid Porin (MPP) Family

Phosphotransferase System (PTS)

GPTS General PTS

SSPTS Sugar Specific PTS

Secondary Transporter

AAA: The ATP:ADP Antiporter (AAA) Family

AAAP: The Amino Acid/Auxin Permease (AAAP) Family

AAE: The Aspartate:Alanine Exchanger (AAE) Family

AbgT: The p-Aminobenzoyl-glutamate Transporter (AbgT) Family

ACR3: The Arsenical Resistance-3 (ACR3) Family

AE: The Anion Exchanger (AE) Family

AEC: The Auxin Efflux Carrier (AEC) Family

AGCS: The Alanine or Glycine:Cation Symporter (AGCS) Family

APC: The Amino Acid-Polyamine-Organocation (APC) Family

ArsB: The Arsenite-Antimonite (ArsB) Efflux Family

BASS: The Bile Acid:Na+ Symporter (BASS) Family

BCCT: The Betaine/Carnitine/Choline Transporter (BCCT) Family

BenE: The Benzoate:H+ Symporter (BenE) Family

CaCA: The Ca2+:Cation Antiporter (CaCA) Family

CadD: The Cadmium Resistance (CadD) Family

CCC: The Cation-Chloride Cotransporter (CCC) Family

CDF: The Cation Diffusion Facilitator (CDF) Family

CHR: The Chromate Ion Transporter (CHR) Family

CitMHS: The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family

ClC: The Chloride Carrier/Channel (ClC) Family

CNT: The Concentrative Nucleoside Transporter (CNT) Family

CPA1: The Monovalent Cation:Proton Antiporter-1 (CPA1) Family

CPA2: The Monovalent Cation:Proton Antiporter-2 (CPA2) Family

CPA3: The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family

DAACS: The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family

DASS: The Divalent Anion:Na+ Symporter (DASS) Family

Dcu: The C4-Dicarboxylate Uptake (Dcu) Family

DcuC: The C4-dicarboxylate Uptake C (DcuC) Family

DMT: The Drug/Metabolite Transporter (DMT) Superfamily

ENT: The Equilibrative Nucleoside Transporter (ENT) Family

ESS: The Glutamate:Na+ Symporter (ESS) Family

FBT: The Folate-Biopterin Transporter (FBT) Family

FNT: The Formate-Nitrite Transporter (FNT) Family

GntP: The Gluconate:H+ Symporter (GntP) Family

GPH: The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family

GUP: The Glycerol Uptake (GUP) Family

HAAAP: The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family

KDGT: The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family

KUP: The K+ Uptake Permease (KUP) Family

LCT: The Lysosomal Cystine Transporter (LCT) Family

LctP: The Lactate Permease (LctP) Family

LIV-E: The Branched Chain Amino Acid Exporter (LIV-E) Family

LIVCS: The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family

LysE: The L-Lysine Exporter (LysE) Family

MC: The Mitochondrial Carrier (MC) Family

MET: The 4 TMS Multidrug Endosomal Transporter (MET) Family

MFS: The Major Facilitator Superfamily (MFS)

MOP: The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily

MSS: The Malonate:Na+ Symporter (MSS) Family

MTC: The Mitochondrial Tricarboxylate Carrier (MTC) Family

NCS1: The Nucleobase:Cation Symporter-1 (NCS1) Family

NCS2: The Nucleobase:Cation Symporter-2 (NCS2) Family

NhaA: The NhaA Na+:H+ Antiporter (NhaA) Family

NhaB: The NhaB Na+:H+ Antiporter (NhaB) Family

NhaC: The NhaC Na+:H+ Antiporter (NhaC) Family

NhaD: The NhaD Na+:H+ Antiporter (NhaD) Family

NiCoT: The Ni2+-Co2+ Transporter (NiCoT) Family

Nramp: The Metal Ion (Mn2+-iron) Transporter (Nramp) Family

NSS: The Neurotransmitter:Sodium Symporter (NSS) Family

OAT: The Organo Anion Transporter (OAT) Family

OPT: The Oligopeptide Transporter (OPT) Family

Oxa1: The Cytochrome Oxidase Biogenesis (Oxa1) Family

PiT: The Inorganic Phosphate Transporter (PiT) Family

PNaS: The Phosphate:Na+ Symporter (PNaS) Family

POT: The Proton-dependent Oligopeptide Transporter (POT) Family

RFC: The Reduced Folate Carrier (RFC) Family

RhtB: The Resistance to Homoserine/Threonine (RhtB) Family

RND: The Resistance-Nodulation-Cell Division (RND) Superfamily

SBT: The Na+-dependent Bicarbonate Transporter (SBT) Family

SSS: The Solute:Sodium Symporter (SSS) Family

SulP: The Sulfate Permease (SulP) Family

Tat: The Twin Arginine Targeting (Tat) Family

TDT: The Telurite-resistance/Dicarboxylate Transporter (TDT) Family

ThrE: The Threonine/Serine Exporter (ThrE) Family

TRAP-T: The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family

Trk: The K+ Transporter (Trk) Family

TTT: The Tricarboxylate Transporter (TTT) Family

ZIP: The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family


FeoB: The Ferrous Iron Uptake (FeoB) Family

FeT: The Low Affinity Fe2+ Transporter (FeT) Family

FP: The Ferroportin (FP) Family

LPI: The Lysosomal Protein Import (LPI) Family

MerTP: The MerTP Mercuric Ion (Hg2+) Permease (MerTP) Family

MgtE: The Mg2+ Transporter-E (MgtE) Family

PPI: The Peroxisomal Protein Importer (PPI) Family

PUP: The Putative Peptide Uptake or Activated Fatty Acid Export Permease (PUP) Family