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Phylogenetics of Transporter Families


Protein sequence in FASTA format
Multiple sequence alignment (View it with JalView)
Multiple sequence alignment (Alignment text file for if JalView does not work, we recommend you run JalView locally in this situation)
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Phylogenetic tree (Phylogram) (View it with Archeopteryx)
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ATP-Dependent

ABC: The ATP-binding Cassette (ABC) Superfamily



ArsAB: The Arsenite-Antimonite (ArsAB) Efflux Family



F-ATPase: The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily



H+-PPase: The H+-translocating Pyrophosphatase (H+-PPase) Family



IISP: The Type II (General) Secretory Pathway (IISP) Family



MPT: The Mitochondrial Protein Translocase (MPT) Family



P-ATPase: The P-type ATPase (P-ATPase) Superfamily


Ion Channels

ACC: The ATP-gated Cation Channel (ACC) Family



Amt: The Ammonia Transporter Channel (Amt) Family



Annexin: The Annexin (Annexin) Family



Bcl-2: The Bcl-2 (Bcl-2) Family



CD20: The CD20 Ca2+ Channel (CD20) Family



Connexin: The Gap Junction-forming Connexin (Connexin) Family



E-ClC: The Epithelial Chloride Channel (E-ClC) Family



ENaC: The Epithelial Na+ Channel (ENaC) Family



GIC: The Glutamate-gated Ion Channel (GIC) Family of Neurotransmitter Receptors



Hsp70: The Cation Channel-forming Heat Shock Protein-70 (Hsp70) Family



ICC: The Intracellular Chloride Channel (ICC) Family



Innexin: The Gap Junction-forming Innexin (Innexin) Family



IRK-C: The Inward Rectifier K+ Channel (IRK-C) Family



LIC: The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family



MID1: The Yeast Stretch-Activated, Cation-Selective, Ca2+ Channel, Mid1 (Mid1) Family



MIP: The Major Intrinsic Protein (MIP) Family



MIT: The CorA Metal Ion Transporter (MIT) Family



MscL: The Large Conductance Mechanosensitive Ion Channel (MscL) Family



MscS: The Small Conductance Mechanosensitive Ion Channel (MscS) Family



NSCC2: The Non-selective Cation Channel-2 (NSCC2) Family



PCC: The Polycystin Cation Channel (PCC) Family



PLM: The Phospholemman (PLM) Family



RIR-CaC: The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family



TRP-CC: The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family



UAC: The Urea/Amide Channel (UAC) Family



UT: The Urea Transporter (UT) Family



VIC: The Voltage-gated Ion Channel (VIC) Superfamily


Outer Membrane Porins

MPP: The Mitochondrial and Plastid Porin (MPP) Family


Phosphotransferase System (PTS)

GPTS General PTS



SSPTS Sugar Specific PTS


Secondary Transporter

AAA: The ATP:ADP Antiporter (AAA) Family



AAAP: The Amino Acid/Auxin Permease (AAAP) Family



AAE: The Aspartate:Alanine Exchanger (AAE) Family



AbgT: The p-Aminobenzoyl-glutamate Transporter (AbgT) Family



ACR3: The Arsenical Resistance-3 (ACR3) Family



AE: The Anion Exchanger (AE) Family



AEC: The Auxin Efflux Carrier (AEC) Family



AGCS: The Alanine or Glycine:Cation Symporter (AGCS) Family



APC: The Amino Acid-Polyamine-Organocation (APC) Family



ArsB: The Arsenite-Antimonite (ArsB) Efflux Family



BASS: The Bile Acid:Na+ Symporter (BASS) Family



BCCT: The Betaine/Carnitine/Choline Transporter (BCCT) Family



BenE: The Benzoate:H+ Symporter (BenE) Family



CaCA: The Ca2+:Cation Antiporter (CaCA) Family



CadD: The Cadmium Resistance (CadD) Family



CCC: The Cation-Chloride Cotransporter (CCC) Family



CDF: The Cation Diffusion Facilitator (CDF) Family



CHR: The Chromate Ion Transporter (CHR) Family



CitMHS: The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family



ClC: The Chloride Carrier/Channel (ClC) Family



CNT: The Concentrative Nucleoside Transporter (CNT) Family



CPA1: The Monovalent Cation:Proton Antiporter-1 (CPA1) Family



CPA2: The Monovalent Cation:Proton Antiporter-2 (CPA2) Family



CPA3: The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family



DAACS: The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family



DASS: The Divalent Anion:Na+ Symporter (DASS) Family



Dcu: The C4-Dicarboxylate Uptake (Dcu) Family



DcuC: The C4-dicarboxylate Uptake C (DcuC) Family



DMT: The Drug/Metabolite Transporter (DMT) Superfamily



ENT: The Equilibrative Nucleoside Transporter (ENT) Family



ESS: The Glutamate:Na+ Symporter (ESS) Family



FBT: The Folate-Biopterin Transporter (FBT) Family



FNT: The Formate-Nitrite Transporter (FNT) Family



GntP: The Gluconate:H+ Symporter (GntP) Family



GPH: The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family



GUP: The Glycerol Uptake (GUP) Family



HAAAP: The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family



KDGT: The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family



KUP: The K+ Uptake Permease (KUP) Family



LCT: The Lysosomal Cystine Transporter (LCT) Family



LctP: The Lactate Permease (LctP) Family



LIV-E: The Branched Chain Amino Acid Exporter (LIV-E) Family



LIVCS: The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family



LysE: The L-Lysine Exporter (LysE) Family



MC: The Mitochondrial Carrier (MC) Family



MET: The 4 TMS Multidrug Endosomal Transporter (MET) Family



MFS: The Major Facilitator Superfamily (MFS)



MOP: The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily



MSS: The Malonate:Na+ Symporter (MSS) Family



MTC: The Mitochondrial Tricarboxylate Carrier (MTC) Family



NCS1: The Nucleobase:Cation Symporter-1 (NCS1) Family



NCS2: The Nucleobase:Cation Symporter-2 (NCS2) Family



NhaA: The NhaA Na+:H+ Antiporter (NhaA) Family



NhaB: The NhaB Na+:H+ Antiporter (NhaB) Family



NhaC: The NhaC Na+:H+ Antiporter (NhaC) Family



NhaD: The NhaD Na+:H+ Antiporter (NhaD) Family



NiCoT: The Ni2+-Co2+ Transporter (NiCoT) Family



Nramp: The Metal Ion (Mn2+-iron) Transporter (Nramp) Family



NSS: The Neurotransmitter:Sodium Symporter (NSS) Family



OAT: The Organo Anion Transporter (OAT) Family



OPT: The Oligopeptide Transporter (OPT) Family



Oxa1: The Cytochrome Oxidase Biogenesis (Oxa1) Family



PiT: The Inorganic Phosphate Transporter (PiT) Family



PNaS: The Phosphate:Na+ Symporter (PNaS) Family



POT: The Proton-dependent Oligopeptide Transporter (POT) Family



RFC: The Reduced Folate Carrier (RFC) Family



RhtB: The Resistance to Homoserine/Threonine (RhtB) Family



RND: The Resistance-Nodulation-Cell Division (RND) Superfamily



SBT: The Na+-dependent Bicarbonate Transporter (SBT) Family



SSS: The Solute:Sodium Symporter (SSS) Family



SulP: The Sulfate Permease (SulP) Family



Tat: The Twin Arginine Targeting (Tat) Family



TDT: The Telurite-resistance/Dicarboxylate Transporter (TDT) Family



ThrE: The Threonine/Serine Exporter (ThrE) Family



TRAP-T: The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family



Trk: The K+ Transporter (Trk) Family



TTT: The Tricarboxylate Transporter (TTT) Family



ZIP: The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family


Unclassified

FeoB: The Ferrous Iron Uptake (FeoB) Family



FeT: The Low Affinity Fe2+ Transporter (FeT) Family



FP: The Ferroportin (FP) Family



LPI: The Lysosomal Protein Import (LPI) Family



MerTP: The MerTP Mercuric Ion (Hg2+) Permease (MerTP) Family



MgtE: The Mg2+ Transporter-E (MgtE) Family



PPI: The Peroxisomal Protein Importer (PPI) Family



PUP: The Putative Peptide Uptake or Activated Fatty Acid Export Permease (PUP) Family