Phylogenetics of Transporter Family


Protein sequence in FASTA format
Multiple sequence alignment (View it with JalView)
TreeView Document (View it with TreeView)
Phylogenetic tree (Phylogram) (View it with ATV)

ATP-Dependent

ABC: The ATP-binding Cassette (ABC) Superfamily



ArsAB: The Arsenite-Antimonite (ArsAB) Efflux Family



CEPT: The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family



F-ATPase: The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily



H+-PPase: The H+-translocating Pyrophosphatase (H+-PPase) Family



IISP: The Type II (General) Secretory Pathway (IISP) Family



MPT: The Mitochondrial Protein Translocase (MPT) Family



P-ATPase: The P-type ATPase (P-ATPase) Superfamily



S-DNA-T: The Septal DNA Translocator (S-DNA-T) Family


Ion Channels

ACC: The ATP-gated Cation Channel (ACC) Family



Amt: The Ammonia Transporter Channel (Amt) Family



Annexin: The Annexin (Annexin) Family



Bcl-2: The Bcl-2 (Bcl-2) Family



Bestrophin: The Anion Channel-forming Bestrophin (Bestrophin) Family



BNip3: The BCL2/Adenovirus E1B-interacting Protein 3 (BNip3) Family



CD20: The CD20 Ca2+ Channel (CD20) Family



CLIC: The Intracellular Chloride Channel (CLIC) Family



Connexin: The Gap Junction-forming Connexin (Connexin) Family



CRAC-C: The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family



Ctr: The Copper Transporter (Ctr) Family



E-ClC: The Epithelial Chloride Channel (E-ClC) Family



ENaC: The Epithelial Na+ Channel (ENaC) Family



GIC: The Glutamate-gated Ion Channel (GIC) Family of Neurotransmitter Receptors



Hsp70: The Cation Channel-forming Heat Shock Protein-70 (Hsp70) Family



ICC: The Intracellular Chloride Channel (ICC) Family



ICln: The Nucleotide-sensitive Anion-selective Channel, ICln (ICln) Family



Innexin: The Gap Junction-forming Innexin (Innexin) Family



IRK-C: The Inward Rectifier K+ Channel (IRK-C) Family



LIC: The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family



Mid1: The Yeast Stretch-Activated, Cation-Selective, Ca2+ Channel, Mid1 (Mid1) Family



MIP: The Major Intrinsic Protein (MIP) Family



MIT: The CorA Metal Ion Transporter (MIT) Family



MscL: The Large Conductance Mechanosensitive Ion Channel (MscL) Family



MscS: The Small Conductance Mechanosensitive Ion Channel (MscS) Family



NSCC2: The Non-selective Cation Channel-2 (NSCC2) Family



PCC: The Polycystin Cation Channel (PCC) Family



Plasmolipin: The Plasmolipin (Plasmolipin) Family



PLB: The Phospholamban (Ca2+-channel and Ca2+-ATPase Regulator) (PLB) Family



PLM: The Phospholemman (PLM) Family



Presenilin: The Presenilin ER Ca2+ Leak Channel (Presenilin) Family



RIR-CaC: The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family



Tic110: The Chloroplast Envelope Anion Channel-forming Tic110 (Tic110) Family



TRIC: The Homotrimeric Cation Channel (TRIC) Family



TRP-CC: The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family



Tweety: The Anion Channel Tweety (Tweety) Family



UAC: The Urea/Amide Channel (UAC) Family



UT: The Urea Transporter (UT) Family



VIC: The Voltage-gated Ion Channel (VIC) Superfamily


Outer Membrane Porins

FadL: The FadL Outer Membrane Protein (FadL) Family



MPP: The Mitochondrial and Plastid Porin (MPP) Family



OMA: The Outer Membrane Auxiliary (OMA) Protein Family



OmpIP: The Outer Membrane Protein Insertion Porin (OmpIP) Family



OMR: The Outer Membrane Receptor (OMR) Family



OOP: The OmpA-OmpF Porin (OOP) Family


Phosphotransferase System (PTS)

GPTS: General PTS



SSPTS: Sugar Specific PTS


Secondary Transporter

2-HCT: The 2-Hydroxycarboxylate Transporter (2-HCT) Family



AAA: The ATP:ADP Antiporter (AAA) Family



AAAP: The Amino Acid/Auxin Permease (AAAP) Family



AAE: The Aspartate:Alanine Exchanger (AAE) Family



AbgT: The p-Aminobenzoyl-glutamate Transporter (AbgT) Family



ACR3: The Arsenical Resistance-3 (ACR3) Family



AE: The Anion Exchanger (AE) Family



AEC: The Auxin Efflux Carrier (AEC) Family



AGCS: The Alanine or Glycine:Cation Symporter (AGCS) Family



AI-2E: The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family, TC #9.B.22)



APC: The Amino Acid-Polyamine-Organocation (APC) Family



ArAE: The Aromatic Acid Exporter (ArAE) Family



ArsB: The Arsenite-Antimonite (ArsB) Efflux Family



AtoE: The Short Chain Fatty Acid Uptake (AtoE) Family



BASS: The Bile Acid:Na+ Symporter (BASS) Family



BCCT: The Betaine/Carnitine/Choline Transporter (BCCT) Family



BenE: The Benzoate:H+ Symporter (BenE) Family



BUT: The Biotin Uptake Transporter (BUT) Family



CaCA: The Ca2+:Cation Antiporter (CaCA) Family



CadD: The Cadmium Resistance (CadD) Family



CCC: The Cation-Chloride Cotransporter (CCC) Family



CDF: The Cation Diffusion Facilitator (CDF) Family



CHR: The Chromate Ion Transporter (CHR) Family



CitMHS: The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family



ClC: The Chloride Carrier/Channel (ClC) Family



CNT: The Concentrative Nucleoside Transporter (CNT) Family



CPA1: The Monovalent Cation:Proton Antiporter-1 (CPA1) Family



CPA2: The Monovalent Cation:Proton Antiporter-2 (CPA2) Family



CPA3: The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family



CTL: The Choline Transporter Like (CTL) Family



DAACS: The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family



DASS: The Divalent Anion:Na+ Symporter (DASS) Family



Dcu: The C4-Dicarboxylate Uptake (Dcu) Family



DcuC: The C4-dicarboxylate Uptake C (DcuC) Family



DMT: The Drug/Metabolite Transporter (DMT) Superfamily



ENT: The Equilibrative Nucleoside Transporter (ENT) Family



ESS: The Glutamate:Na+ Symporter (ESS) Family



FBT: The Folate-Biopterin Transporter (FBT) Family



FNT: The Formate-Nitrite Transporter (FNT) Family



GntP: The Gluconate:H+ Symporter (GntP) Family



GPH: The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family



GUP: The Glycerol Uptake (GUP) Family



HAAAP: The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family



KDGT: The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family



KUP: The K+ Uptake Permease (KUP) Family



LCT: The Lysosomal Cystine Transporter (LCT) Family



LctP: The Lactate Permease (LctP) Family



LIV-E: The Branched Chain Amino Acid Exporter (LIV-E) Family



LIVCS: The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family



LysE: The L-Lysine Exporter (LysE) Family



MC: The Mitochondrial Carrier (MC) Family



MET: The 4 TMS Multidrug Endosomal Transporter (MET) Family



MEX: The Chloroplast Maltose Exporter (MEX) Family



MFS: The Major Facilitator Superfamily (MFS)



MOP: The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily



MSS: The Malonate:Na+ Symporter (MSS) Family



MTC: The Mitochondrial Tricarboxylate Carrier (MTC) Family



NCS1: The Nucleobase:Cation Symporter-1 (NCS1) Family



NCS2: The Nucleobase:Cation Symporter-2 (NCS2) Family



NhaA: The NhaA Na+:H+ Antiporter (NhaA) Family



NhaB: The NhaB Na+:H+ Antiporter (NhaB) Family



NhaC: The NhaC Na+:H+ Antiporter (NhaC) Family



NhaD: The NhaD Na+:H+ Antiporter (NhaD) Family



NiCoT: The Ni2+-Co2+ Transporter (NiCoT) Family



Nramp: The Metal Ion (Mn2+-iron) Transporter (Nramp) Family



NSS: The Neurotransmitter:Sodium Symporter (NSS) Family



OAT: The Organo Anion Transporter (OAT) Family



OPT: The Oligopeptide Transporter (OPT) Family



OST: The Organic Solute Transporter (OST) Family



Oxa1: The Cytochrome Oxidase Biogenesis (Oxa1) Family



PiT: The Inorganic Phosphate Transporter (PiT) Family



PNaS: The Phosphate:Na+ Symporter (PNaS) Family



POT: The Proton-dependent Oligopeptide Transporter (POT) Family



RFC: The Reduced Folate Carrier (RFC) Family



RFT: The Riboflavin Transporter (RFT) Family



RhtB: The Resistance to Homoserine/Threonine (RhtB) Family



RND: The Resistance-Nodulation-Cell Division (RND) Superfamily



SBT: The Na+-dependent Bicarbonate Transporter (SBT) Family



Sit: The Silicon Transporter (Sit) Family



SSS: The Solute:Sodium Symporter (SSS) Family



STRA6: The Vitamin A Receptor/Transporter (STRA6) Family



SulP: The Sulfate Permease (SulP) Family



Tat: The Twin Arginine Targeting (Tat) Family



TDT: The Telurite-resistance/Dicarboxylate Transporter (TDT) Family



ThrE: The Threonine/Serine Exporter (ThrE) Family



TRAP-T: The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family



Trk: The K+ Transporter (Trk) Family



TTT: The Tricarboxylate Transporter (TTT) Family



VIT: The Vacuolar Iron Transporter (VIT) Family



ZIP: The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family


Unclassified

ATP-E: The ATP Exporter (ATP-E) Family



CPS-E: The Capsular Polysaccharide Exporter (CPS-E) Family



dsRNA-T: The Double Stranded RNA Transporter (dsRNA-T) Family



EAF: The Ethanolamine Facilitator (EAF) Family



FeoB: The Ferrous Iron Uptake (FeoB) Family



FeT: The Low Affinity Fe2+ Transporter (FeT) Family



FP: The Ferroportin (FP) Family



GAP: The Peptidoglycolipid Addressing Protein (GAP) Family



HCC: The HlyC/CorC (HCC) Family



ILT: The Iron/Lead Transporter (ILT) Superfamily



LPI: The Lysosomal Protein Import (LPI) Family



LTE: The Lipid-translocating Exporter (LTE) Family



MagT1: The Magnesium Transporter1 (MagT1) Family



MerTP: The MerTP Mercuric Ion (Hg2+) Permease (MerTP) Family



MgtE: The Mg2+ Transporter-E (MgtE) Family



N-MDE: The Non ABC Multidrug Exporter (N-MDE) Family



NIPA: The NIPA Mg2+ Uptake Permease (NIPA) Family



PPI: The Peroxisomal Protein Importer (PPI) Family



PPI2: The Integral Membrane Peroxisomal Protein Importer-2 (PPI2) Family



PUP: The Putative Peptide Uptake or Activated Fatty Acid Export Permease (PUP) Family



SdpI: The SdpC (Peptide-Antibiotic Killer Factor) Immunity Protein, SdpI (SdpI) Family



TerC: The Tellurium Ion Resistance (TerC) Family



TSUP: The Putative 4-Toluene Sulfonate Uptake Permease (TSUP) Family



YggT: The YggT or Fanciful K+ Uptake-B (FkuB; YggT) Family