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Ian T. Paulsen, Ph.D.
Professor

____Contact Details_____________________
Professor Ian Paulsen
Department of Chemistry and Biomolecular Sciences
Macquarie University
Sydney, NSW, Australia, 2109

Email: ian.paulsen@mq.edu.au
Phone: 61 2 9850 8152
Fax: 61 2 9850 8313


____Research Interests_____________________
My research interests have focused on understanding microbial physiology and evolution, in particular in utilizing "big picture" or global approaches such as genome sequencing, bioinformatics, microarray analysis, and high throughput cloning, gene knockout, and phenotypic screening. My research interests have been focused in three broad areas:

  • Genome diversity, metagenomics and lateral gene transfer
  • System biology analysis of membrane transport and metabolism
  • Applying Genomics to Medicine

    ____Education_____________________________
    Ph.D., Medicine, Monash University, Melbourne, Australia & University of Sydney, Sydney, Australia, 1994
    B.Sc.(Hons), Microbiology, Monash University, Melbourne, Australia, 1989

    ____Experience____________________________
    2007 - present: Professor, Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia
    2007 - present: Adjunct Associate Investigator, J. Craig Venter Institute, Rockville, MD, USA
    2003 - 2007: Associate Investigator, The Institute for Genomic Research, Rockville, MD, USA
    2000 - 2003: Assistant Investigator, The Institute for Genomic Research, Rockville, MD, USA
    2000 - 2007: Adjunct Assistant Professor, Johns Hopkins University, Department of Biology, Baltimore, USA
    1998 - 1999: Assistant Project Scientist, Department of Biology, University of California at San Diego, La Jolla, CA, USA
    1997 - 1998: C.J. Martin Postdoctoral Fellow, School of Biological Sciences, University of Sydney,Sydney, Australia
    1995 - 1997: C.J. Martin Postdoctoral Fellow, Department of Biology, University of California at San Diego, La Jolla, CA, USA

    ____Honors/Awards/Societies_______________________________
    2007 - present: Editorial Board, Journal of Molecular Microbiology and Biotechnology
    2007 - present: Editorial Board, Journal of Microbial Ecology
    2007 - present: ISI Highly Cited Author
    2001 - 2004: Member, Faculty of 1000
    1995 - 1999:C.J. Martin Fellowship; National Health and Medical Research Council, Australia
    1990 - 1994:Sir Ernest Fields Memorial Scholarship

    ____Selected Publications (Out of a total of 130+ papers)___________________
    1. Myers, G. S, Parker, D., Al-Hasani, K., Kennan, R. M., Seemann, T., Ren, Q., Badger, J. H., Selengut, J. D., Deboy, R. T., Tettelin, H., Boyce, J. D., McCarl, V. P., Han, X., Nelson, W. C., Madupu, R., Mohamoud, Y., Holley, T., Fedorova, N., Khouri, H., Bottomley, S. P., Whittington, R. J., Adler, B., Songer, J. G., Rood, J. I, and Paulsen, I. T. (2007) Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nature Biotechnology 25:569-575.
    2. Ren, Q., Chen, K., and Paulsen, I. T. (2007) TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Research 35: D274-279.
    3. Palenik, B., Ren, Q., Dupont, C. L., Myers, G. S., Heidelberg, J. F., Badger, J. H., Madupu, R., Nelson, W. C., Brinkac, L. M., Dodson, R. J., Durkin, A. S., Daugherty, S. C., Sullivan, S. A., Khouri, H., Mahamoud, Y., Halpin, R., and Paulsen, I. T. (2006) Genome sequence of Synechococcus CC9311: Insights into adaptation to a coastal environment. Proceedings of the National Academy of Sciences, USA 103: 13555-13559.
    4. Myers, G. S. A, Rasko, D. A., Cheung, J., Ravel, J., Seshadri, R., DeBoy, R., Varga, J., Awad, M., Brinkac, L., Daugherty, S., Dodson, B., Madupu, R., Nelson, W., Rosovitz, M. J., Sullivan, S., Khouri, H., Dimitrov, G., Watkins, K., Mulligan, S., Benton, J., Fisher, D. J., Atkins, H. S., Hiscox, T., Jost, H., Billington, S., Songer, J. G., McClane, B. A., Titball, R. W., Rood, J. I., Melville, S., and Paulsen, I. T. (2006) Skewed distribution of genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Research 16: 1031-1040.
    5. Ding, X. Z., Paulsen, I. T., Bhattacharjee, A., Nikolich, M. P., Myers, G. and Hoover, D. L. (2006) A high efficiency cloning and expression system for proteomic analysis. Proteomics 6: 4038-4044.
    6. Keseler, I. M., Collado-Vides, J., Gama-Castro, S., Ingraham, J., Paley, S., Paulsen, I. T., Peralta-Gil, M., and Karp, P. D. (2005) EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Research 33: D334-337.
    7. Paulsen, I. T., Press, C., Ravel, J., Kobayashi, D.Y., Myers, G.S.A., Mavrodi, D.V., DeBoy, R.T., Seshadri, R., Ren, Q., Madupu, R., Dodson, R.J., Durkin, A.S., Brinkac, L.M., Daugherty, S.C., Sullivan, S.A., Rosovitz, M.J., Gwinn, M.L., Zhou, L., Nelson, W.C., Weidman, J., Watkins, K., Tran, K., Khouri, H., Pierson, E.A., Pierson, L.S., III, Thomashow, L.S., and Loper, J.E. (2005) Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5: insights into the biological control of plant disease. Nature Biotechnology 23: 873-878.
    8. Ren, Q. and Paulsen, I. T. (2005) Comparative Analyses of Fundamental Differences in Membrane Transport Capabilities in Prokaryotes and Eukaryotes. PLOS Computational Biology 1: 190-201
    9. Ren, Q., Kang, K., and Paulsen, I. T. TransportDB: a relational database of cellular membrane transport systems (2004) Nucleic Acids Research 32: 284-288.
    10. Seshadri, R., Myers, G. S., Tettelin. H., Eisen, J. A., Heidelberg, J. F., Dodson, R. J., Davidsen, T. M., DeBoy, R. T., Fouts, D. E., Haft, D. H., Selengut, J., Ren, Q., Brinkac, L. M., Madupu, R., Kolonay, J., Durkin, S. A., Daugherty, S. C., Shetty, J., Shvartsbeyn, A., Gebregeorgis, E., Geer, K., Tsegaye, G., Malek, J., Ayodeji, B., Shatsman, S., McLeod, M. P., Smajs, D., Howell, J. K., Pal, S., Amin, A., Vashisth, P., McNeill, T. Z., Xiang, Q., Sodergren, E., Baca, E., Weinstock, G. M., Norris, S. J., Fraser, C. M., and Paulsen, I. T. (2004) Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proceedings of the National Academy of Sciences, USA 101: 5646-5651.
    11. Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., Fouts, D. E., Levy, S., Knap, A. H., Lomas, M. W., Nealson, K., White, O., Peterson, J., Hoffman, J., Parsons, R., Baden-Tillson, H., Pfannkoch, C., Rogers, Y. H., and Smith, H. O. (2004). Environmental genome shotgun sequencing of the Sargasso Sea. Science 304: 66-74.
    12. Paulsen, I. T., Banerjei, L., Myers, G. S., Nelson, K. E., Seshadri, R., Read, T. D., Fouts, D. E., Eisen, J. A., Gill, S. R., Heidelberg, J. F., Tettelin, H., Dodson, R. J., Umayam, L., Brinkac, L., Beanan, M., Daugherty, S., DeBoy, R. T., Durkin, S., Kolonay, J., Madupu, R., Nelson, W., Vamathevan, J., Tran, B., Upton, J., Hansen, T., Shetty, J., Khouri, H., Utterback, T., Radune, D., Ketchum, K. A., Dougherty, B. A., and Fraser, C. M. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. (2003) Science 299: 2071-2074.
    13. Paulsen, I. T. (2003) Multidrug efflux pumps and resistance: regulation and evolution. Current Opinion in Microbiology 6: 446-451.

    ____Web Sites___________________
    TransportDB: A database of genomic analysis of transporters in all sequenced genomes which my group developed and maintains.
    EcoCyc: A comprehensive database of E. coli genes and biology, on which I have been a long term collaborator with Peter Karp at SRI International.

    ____Public Outreach___________________
    I have participated in a variety of public outreach activities to foster integration of research and education, and to make scientific research more accessible to the general public:

  • Sea of Genes: an exhibition on marine genomics at the Birch Aquarium in La Jolla, California which was organized as part of an NSF-funded sequencing led by myself and Brian Palenik at Scripps Institute of Oceanography.
  • Interview on the ABC Science Show: Interview with Robyn Williams on the Enterococcus genome
  • Boosting BioControl: Very short interview on MicrobeWorld Radio.

    ____Press Releases and News Articles___________________

  • Genomic technology provides footrot breakthrough
  • Surf's Up-And One Coastal Microbe Has Adapted
  • Cell Scenario: A New Look at Microarrays
  • Genome Study of Beneficial Microbe May Help Boost Plant Health
  • A New Spin on Spirochetes
  • Scientists Finish Sequencing Genome of Oral Pathogen
  • Thomson Scientific Names "Hottest" Researchers 2004
  • The Hottest Research of 2003-2004
  • Aliens Inside Us: A (Mostly Friendly) Nation
  • Genome Analysis Sheds Light on Mobile DNA's Role in Pathogen's Resistance to Vancomycin
  • Deciphering the "Bugs" in Human Intestines
  • Microbial Multidrug Efflux
  • Genome of Potential Bioterror Agent Sequenced; Highlights Similarities Between Animal, Plant Pathogens
  • U.S. - German Research Consortium Sequences Genome of Versatile Soil Microbe
  • Biolog Phenotype Microarrays
  • The Genome of Agrobacterium tumefaciens A plant pathogen with a talent for transferring genes

  •  

      Professor
    Group Leader

      (JCVI)
    Bioinformatics Scientist
    Lead developer of TransportDB

      (JCVI)
    Research Assistant
    Curator of EcoCyc

      (Macquarie)
    Post-Doctoral Fellow

      (Macquarie)
    Post-Doctoral Fellow

      (Macquarie)
    Research Fellow

    Amanda Mackie
      (Macquarie)
    Curator of EcoCyc
    Lab Manager
    Research Assistant

      (Macquarie)
    PhD Student

    Daniel Farrugia
      (Macquarie)
    PhD Student

    Bhumika Shah
      (Macquarie)
    PhD Student

    Katy Breakwell
      (Macquarie)
    Honours Student

    Liping Li
      (Macquarie)
    Honours Student

      (Macquarie)
    PhD Student
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